The royal figure surrenders his honor as the Duke.
The royal is surrendering his titles, among them the Duke of York, he has declared in a individual message.
He has been under mounting scrutiny over his links with disgraced financier Jeffrey Epstein, with requests for the royal household to take measures against him.
That now appears to have led to the royal deciding to willingly give up his designations and to surrender participation of the prestigious order.
In his message he said he continued to "strongly refute the claims against me".
"In talks with the King, and my close and wider family, we have agreed the persistent allegations about me take away from the duties of the monarch and the monarchy," said a announcement from Prince Andrew.
"I have chosen, as I always have, to put my duty to my kin and nation first.
"I support my choice five years ago to step back from royal engagements.
"With the King's approval, we feel I must now go a additional measure. I will therefore no longer use my honor or the distinctions which have been granted to me. As I have said before, I vigorously dispute the accusations against me."
The royal has faced a series of issues, among them a legal case he resolved with the plaintiff, inquiries about his finances and his association with an accused foreign agent.
He will continue to be a prince - but will cease to be the Duke of York, a designation bestowed from his the late Queen, the former monarch.
He had already ended to be a "participating figure" and had given up the use of his His Royal Highness designation and no longer appeared at public engagements. His status now will be even more diminished.
His ex-wife will be known as Sarah Ferguson and no longer the Duchess, but their offspring will continue to have the title of royal princess.
Prince Andrew has been under strong scrutiny over his associations with convicted sex offender Jeffrey Epstein, more lately featuring inquiries about when he had really cut off ties.
In his television appearance, the royal had said that he had cut off all links with Epstein after they had been pictured together in the city in the end of 2010.
But correspondence sent in early 2011 later came to light implying that he had confidentially remained in touch with Epstein, for example swapping a note: "Stay in contact and we'll have further interactions soon!"
There had been growing displeasure in the monarchy at the issues that persisted to envelop the royal.
In the coming days a book released after death by Virginia Giuffre will be issued which is anticipated to bring additional attention on his connection with Ms Giuffre and the financier.